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BIBTEX RIS

Adenanthera pavonina galactomannan for controlled delivery of rutin – a preliminary study

2018; Brazilian Chemical Society; Linguagem: Inglês

10.21577/0100-4042.20170226

ISSN

1678-7064

Autores

Karine A. Nobre, Carlos Eduardo Alves Soares, Ícaro Gusmão Pinto Vieira, Raimundo Rafael de Almeida, Renato de Azevedo Moreira, Tamara Gonçalves de Araújo, Maria Elenir Nobre Pinho Ribeiro, Nágila Maria Pontes Silva Ricardo,

Tópico(s)

Ginkgo biloba and Cashew Applications

Resumo

Improving the development of modified release matrix systems strictly depends on selecting an appropriate agent capable of controlling the drug's release.In this study, Adenanthera pavonina galactomannan was investigated as a potential basis for developing a controlled release of rutin.This galactomannan was extracted, purified and characterized by GPC, NMR and FT-IR spectroscopy.The mannose/galactose ratio (M/G) of 1.46 was calculated by the relative area from signals of the anomeric region of 1 H-NMR spectrum.The main chain of this galactomannan consists of β(1→4)-D-mannose and α(1→6)-D-galactose linked units ( 1 H-decoupled 13 C NMR, 13 C DEPT 135º NMR and HSQC spectra).The sustained-release tablets containing rutin and galactomannan were compared with the extensively investigated hydrophilic matrix HPMC.Drug release analysis revealed similar release mechanism for both matrices.A new formulation for controlled drug delivery from water-swellable matrix systems is proposed.

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