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Coinfection with Zika Virus (ZIKV) and Dengue Virus Results in Preferential ZIKV Transmission by Vector Bite to Vertebrate Host

2018; Oxford University Press; Volume: 218; Issue: 4 Linguagem: Inglês

10.1093/infdis/jiy196

1537-6613

Bárbara Aparecida Chaves, Alessandra S Orfanó, Paula Monalisa Nogueira, Nilton Barnabé Rodrigues, Thaís Bonifácio Campolina, Rafael Nacif-Pimenta, Ana Clara Araújo Machado Pires, Ademir Bentes Vieira Júnior, Andréia da Costa Paz, Evelyn Beatriz da Costa Vaz, Maria das Graças Vale Barbosa Guerra, Breno de Mello Silva, Fabrício Freire de Melo, Douglas E. Norris, Marcus Lacerda, Paulo Filemon Paolucci Pimenta, Nágila Francinete Costa Secundino,

Malaria Research and Control

Several tropical cities are permissive to Aedes aegypti and dengue virus (DENV) endemicity and have allowed for invasion and circulation of Zika virus (ZIKV) in the same areas. People living in arbovirus-endemic regions have been simultaneously infected with ≥2 arboviruses. A. aegypti mosquitoes from Manaus, the capital city of Amazonas State in Brazil, were coinfected with circulating strains of DENV and ZIKV. The coinfected vectors were allowed to bite BALB/c mice. A. aegypti from Manaus is highly permissive to monoinfection and coinfection with DENV and ZIKV and is capable of cotransmitting both pathogens by bite. Coinfection strongly influences vector competence, favoring transmission of ZIKV to the vertebrate host. This finding suggests that A. aegypti is an efficient vector of ZIKV and that ZIKV would be preferentially transmitted by coinfected A. aegypti. Coinfection in the vector population should be considered a new critical epidemiological factor and may represent a major public health challenge.