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Household Transmission of Ebola Virus: Risks and Preventive Factors, Freetown, Sierra Leone, 2015

2018; Oxford University Press; Volume: 218; Issue: 5 Linguagem: Inglês

10.1093/infdis/jiy204

1537-6613

M. R. Reichler, James Bangura, Dana Bruden, Charles Keimbe, Nadezhda Duffy, Harold Thomas, Barbara Knust, Ishmail Farmar, Erin Nichols, Amara Jambai, Oliver Morgan, Thomas Hennessy, Francis Davies, Mohamed Sima Dumbuya, Hannah Kamara, Mohamed Yayah Kallon, Joseph Kpukumu, Sheku Abu, Fatmata Bangura, Saidu Rahim Bangura, Tomeh Bangura, Hassan Benya, Sandi Blango, Imurana Conteh, Peter Conteh, Bintu Jabbie, Sheku Jabbie, Luseni Kamara, Francis Lansana, Maada Rogers, Sahr Brima Sewa, Matthew Yamba, Patricia A. Bessler, Shelley Campbell, Wendy Chung, Elizabeth Ervin, S Herse,

COVID-19 epidemiological studies

Knowing risk factors for household transmission of Ebola virus is important to guide preventive measures during Ebola outbreaks. We enrolled all confirmed persons with Ebola who were the first case in a household, December 2014–April 2015, in Freetown, Sierra Leone, and their household contacts. Cases and contacts were interviewed, contacts followed prospectively through the 21-day incubation period, and secondary cases confirmed by laboratory testing. We enrolled 150 index Ebola cases and 838 contacts; 83 (9.9%) contacts developed Ebola during 21-day follow-up. In multivariable analysis, risk factors for transmission included index case death in the household, Ebola symptoms but no reported fever, age <20 years, more days with wet symptoms; and providing care to the index case (P < .01 for each). Protective factors included avoiding the index case after illness onset and a piped household drinking water source (P < .01 for each). To reduce Ebola transmission, communities should rapidly identify and follow-up all household contacts; isolate those with Ebola symptoms, including those without reported fever; and consider closer monitoring of contacts who provided care to cases. Households could consider efforts to minimize risk by designating one care provider for ill persons with all others avoiding the suspected case.