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Artigo Produção Nacional Revisado por pares
BIBTEX RIS

Cerebellar degeneration and progressive ataxia associated with HIV-virus infection

2018; Elsevier BV; Volume: 54; Linguagem: Inglês

10.1016/j.parkreldis.2018.04.007

ISSN

1873-5126

Autores

José Luiz Pedroso, Thiago Cardoso Vale, Maria Thereza Drumond Gama, Gustavo Ribas, Julio C.G. Kristochik, Francisco Manoel Branco Germiniani, Maria Cristina Domingues da Silva Fink, Augusto César Penalva de Oliveira, Hélio Afonso Ghizoni Teive, Orlando Graziani Póvoas Barsottini,

Tópico(s)

Infectious Encephalopathies and Encephalitis

Resumo

Introduction The spectrum of neurologic disorders associated with HIV infection is very broad, resulting from direct virus invasion, opportunistic infections, malignancies and toxic effects of drugs. Methods Among a large cohort of ataxia patients (N = 1050) evaluated between 2008 and 2017, we detected four patients with HIV-infection who developed a pure progressive cerebellar ataxia syndrome combined with cerebellar atrophy. Results Adverse drug effects, opportunistic infections and malignancies as well as immune-reconstitution syndrome were ruled out based on history and laboratory data. The exact pathophysiological mechanisms of ataxia in HIV patients is not very clear, but seems to be immune-mediated or a direct neurotoxic virus effect leading to apoptosis of Purkinje and granular cells. Conclusion HIV infection should be investigated in adult patients with undetermined sporadic progressive pure ataxia with cerebellar atrophy.

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