closo -Dodecaborate-conjugated human serum albumins: preparation and in vivo selective boron delivery to tumor
2018; International Union of Pure and Applied Chemistry; Volume: 90; Issue: 4 Linguagem: Inglês
10.1515/pac-2017-1104
ISSN1365-3075
AutoresHiroyuki Nakamura, Shunsuke Kikuchi, Kazuki Kawai, Satomu Ishii, Shinichi Sato,
Tópico(s)Nanoparticle-Based Drug Delivery
ResumoAbstract Maleimide-functionalized closo -dodecaborate (MID) and isothiocyanate-functionalized closo -dodecaborate (ISD) were synthesized from closo -dodecaborate via ring opening reaction of 1,4-dioxane- closo -dedecaborate complex 1 with ammonia. MID was found to possess highest conjugation efficacy to bovine serum albumin among three closo -dodecaborate derivatives, MID, ISD, and 1 . The conjugation reaction of MID to human serum albumin (HSA) proceeded under PBS buffer conditions (pH 7.4). Boron distribution studies in colon 26 tumor-bearing mice revealed that HSA-MID was highly accumulated in tumor (23 ppm B), whereas boron concentrations in other organs such as liver, kidney and spleen were low (3~8 ppm B).
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