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Revisão Produção Nacional Revisado por pares

BIBTEX RIS

Alternative Methods to Animal Studies for the Evaluation of Topical/ Transdermal Drug Delivery Systems

2018; Bentham Science Publishers; Volume: 18; Issue: 4 Linguagem: Inglês

10.2174/1568026618666180412153214

1873-4294

Maria Teresa Junqueira Garcia, Fabia Leal Lopes de Vasconcellos, Chloe Patricia Raffier, Michael S. Roberts, Jeffrey E. Grice, Heather A. E. Benson, Vânia Rodrigues Leite‐Silva,

Toxin Mechanisms and Immunotoxins

It is critical to develop an effective understanding of the interaction between the drug, delivery system and skin in order to predict and assess skin penetration and permeation. Experimental models for the assessment of topical and transdermal delivery systems must permit evaluation of these complex interactions. Whilst in the past, animal models were commonly used, recent regulatory guidelines, based on 3R principles (refinement, reduction, replacement), encourage the rational use of animals. Alternative methods have been proposed for use in the development of topical and transdermal delivery systems which are often used in combination. We will review the current state of the art in alternative methods for topical and transdermal delivery systems development, including technologies that can assist in the characterization of skin penetration/permeation studies.