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Areas of Effectiveness of Defibrillating Pulse in the Energy/Phase Diagram for the Fibrillation Cycle on the Cardiomyocyte Model

2018; Linguagem: Inglês

10.29007/n83c

2516-2314

Boris B. Gorbunov, В. А. Востриков, И. В. Нестеренко, D. V. Telyshev,

Solid-state spectroscopy and crystallography

In the BeatBox simulation environment on the human heart ventricle myocyte model ten Tusscher-Panfilov 2006 the efficiency areas of the depolarizing defibrillation pulse in the energy/phase diagram for the fibrillation cycle are investigated. At any energy levels, the depolarizing pulse does not provide a long-term extension of refractoriness of all heart cardiomyocytes in different phases of the excitation wave cycle, but at a certain energy level, refractoriness is long-term extended in 90% of the cardiomyocytes in different phases of the fibrillation wave cycle. At high energy levels, the action of the depolarizing pulse leads to a one-time extension of the refractory period of cardiomyocytes to values exceeding the duration of the fibrillation wave period. Presumably long-term extension of refractoriness of cardiomiocites at low energy of depolarising pulse and one-time extension of refractoriness of all cardiomiocites at high energy of depolarising pulse are the mechanisms of defibrillation.