Portal de Periódicos da CAPES

Genetic and mechanistic diversity in pediatric hemophagocytic lymphohistiocytosis

2018; Elsevier BV; Volume: 132; Issue: 1 Linguagem: Inglês

10.1182/blood-2017-11-814244

1528-0020

Iván K. Chinn, Olive S. Eckstein, Erin C. Peckham‐Gregory, Baruch R. Goldberg, Lisa R. Forbes, Sarah K. Nicholas, Emily M. Mace, Tiphanie P. Vogel, Harshal Abhyankar, María I. Díaz, Helen E. Heslop, Robert A. Krance, Caridad Martinez, Trung C. Nguyen, Dalia Bashir, Jordana Goldman, Asbjørg Stray‐Pedersen, Luis Alberto Pedroza, M. Cecilia Poli, Juan Carlos Aldave Becerra, Sean McGhee, Waleed Al‐Herz, Aghiad Chamdin, Zeynep Coban‐Akdemir, Shalini N. Jhangiani, Donna M. Muzny, Tram N. Cao, Diana N. Hong, Richard A. Gibbs, James R. Lupski, Jordan S. Orange, Kenneth L. McClain, Carl E. Allen,

Parvovirus B19 Infection Studies

Key Points Whole-exome sequencing may identify specific therapeutic opportunities for patients with HLH. HLH should be conceptualized as a critical illness phenotype driven by toxic activation of immune cells from different underlying mechanisms.