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Genomic and epidemiological monitoring of yellow fever virus transmission potential

2018; American Association for the Advancement of Science; Volume: 361; Issue: 6405 Linguagem: Inglês

10.1126/science.aat7115

1095-9203

Nuno R. Faria, Moritz U. G. Kraemer, Sarah C. Hill, Jaqueline Góes de Jesus, Renato Santana Aguiar, Felipe Campos de Melo Iani, Joilson Xavier, Josh Quick, Louis du Plessis, Simon Dellicour, Julien Thézé, Rodrigo Dias de Oliveira Carvalho, Guy Baele, Chieh‐Hsi Wu, Paola Paz Silveira, Mônica Arruda, Mariza Pereira, G. C. Pereira, José Lourenço, Uri Obolski, Leandro Abade, Tetyana I. Vasylyeva, Marta Giovanetti, Dong‐Keun Yi, D. J. Weiss, William Wint, Freya M. Shearer, Sebastian Funk, Birgit Nikolay, Vagner Fonseca, Talita Adelino, Marluce Aparecida Assunção Oliveira, Marcos Vinícius Ferreira Silva, Lívia Sacchetto, P. O. Figueiredo, Izabela Maurício de Rezende, Érica Munhoz de Mello, Rana Said, D. A. Santos, Marcela Lencine Ferraz, Mariana Gontijo de Brito, L. F. Santana, Mariane Talon de Menezes, Rodrigo Brindeiro, Amílcar Tanuri, Fabiana Cristina Pereira dos Santos, Mariana Sequetin Cunha, Juliana Silva Nogueira, Iray Maria Rocco, Antônio Charlys da Costa, Shirley Vasconcelos Komninakis, Vasco Azevedo, Alexandre Chieppe, Eliane Saraiva Machado de Araújo, Marcos César Lima de Mendonça, C. C. dos Santos, Chagas Dos Santos, A. M. Mares-Guia, Rita Maria Ribeiro Nogueira, Patrícia Carvalho de Sequeira, Ricardo Gadelha de Abreu, M. H. O. Garcia, André Luiz de Abreu, Osnei Okumoto, Erna Geessien Kroon, Carlos F. Campelo de Albuquerque, Kuiama Lewandowski, Steven T. Pullan, Miles W. Carroll, Túlio de Oliveira, Éster Cerdeira Sabino, Renato Pereira de Souza, Marc A. Suchard, Philippe Lemey, G. S. Trindade, Betânia Paiva Drumond, Ana María Bispo de Filippis, Nicholas J. Loman, Simon Cauchemez, Luíz Carlos Júnior Alcântara, Oliver G. Pybus,

Insect symbiosis and bacterial influences

The yellow fever virus (YFV) epidemic in Brazil is the largest in decades. The recent discovery of YFV in Brazilian Aedes species mosquitos highlights a need to monitor the risk of reestablishment of urban YFV transmission in the Americas. We use a suite of epidemiological, spatial, and genomic approaches to characterize YFV transmission. We show that the age and sex distribution of human cases is characteristic of sylvatic transmission. Analysis of YFV cases combined with genomes generated locally reveals an early phase of sylvatic YFV transmission and spatial expansion toward previously YFV-free areas, followed by a rise in viral spillover to humans in late 2016. Our results establish a framework for monitoring YFV transmission in real time that will contribute to a global strategy to eliminate future YFV epidemics.