Differences in Cell-Cycle Progression Delays after Exposure to 238 Pu a Particles Compared to X Rays
1980; Radiation Research Society; Volume: 84; Issue: 1 Linguagem: Inglês
10.2307/3575213
ISSN1938-5404
AutoresM.R. Raju, Tod S. Johnson, N. Tokita, S.G. Carpenter, James H. Jett,
Tópico(s)Radiation Therapy and Dosimetry
ResumoCultured Chinese hamster cells (V79) were exposed to /sup 238/Pu ..cap alpha.. particles or 250 kVp x rays at doses resulting in similar cell survivals (i.e., 50, 10, and 1%). The DNA distributions of cells at different times after radiation exposure were measured using flow cytometry. Results indicated that after exposure to ..cap alpha.. particles, V79 cells showed significantly prolonged late S phase delay compared to x rays for comparable cell-killing doses. Retention of cells in late S subsequent to ..cap alpha..-particle exposure caused a longer mitotic delay compared to x rays for a given survival level, consistent with the observation that for the endpoint of mitotic delay the RBE for high-LET radiation is higher than the RBE for cell killing.
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