Perioperative and Survival Outcomes Following Neoadjuvant FOLFIRINOX versus Gemcitabine Abraxane in Patients with Pancreatic Adenocarcinoma.
2018; National Institutes of Health; Volume: 19; Issue: 2 Linguagem: Inglês
Autores
Brandon C. Chapman, Ana Gleisner, Devin Rigg, Wells A. Messersmith, Alessandro Paniccia, Cheryl Meguid, Csaba Gajdos, Martin D. McCarter, Richard D. Schulick, Barish H. Edil,
Tópico(s)Cancer Genomics and Diagnostics
ResumoNeoadjuvant chemotherapy is increasingly used in borderline resectable and locally advanced pancreatic cancer to facilitate surgical resection.To compare progression free survival and overall survival in patients receiving neoadjuvant FOLFIRINOX with those receiving gemcitabine/abraxane.Retrospective cohort study.University of Colorado Hospital from 2012-2016.Patients with pancreatic adenocarcinoma.Neoadjuvant FOLFIRINOX or gemcitabine/abraxane.Perioperative outcomes, progression free survival, and overall survival were compared between groups. A multivariate Cox proportional hazard model was applied to evaluate survival outcomes.We identified 120 patients: 83 (69.2%) FOLFIRINOX and 37 (30.8%) gemcitabine/abraxane. The FOLIFRINOX group was younger and had a lower ECOG performance status (p 0.05). Insulin-dependent diabetes and a poor-to-moderate pathologic response was associated with worse progression free survival and overall survival.Neoadjuvant FOLFIRINOX may improve progression free survival by increasing the proportion of patients undergoing surgical resection. Improved understanding of the role for selection bias and longer follow up are needed to better define the impact of neoadjuvant FOLFIRINOX on overall survival.
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