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Patients with high serum substance P levels previously to liver transplantation for hepatocellular carcinoma have higher risk of one-year liver transplantation mortality

2018; Impact Journals LLC; Volume: 9; Issue: 30 Linguagem: Inglês

10.18632/oncotarget.25097

1949-2553

Leonardo Lorente, Sergio Rodriguez, Pablo Sanz-Ruíz, Antonia Pérez-Cejas, Javier Padilla, Dácil Díaz, Antonio González, María M. Martín, Alejandro Jiménez, Purificación Cerro, Manuel Barrera,

Hormonal Regulation and Hypertension

// Leonardo Lorente 1 , Sergio T. Rodriguez 2 , Pablo Sanz 3 , Antonia Pérez-Cejas 4 , Javier Padilla 3 , Dácil Díaz 5 , Antonio González 5 , María M. Martín 2 , Alejandro Jiménez 6 , Purificación Cerro 7 and Manuel A. Barrera 3 1 Intensive Care Unit, Hospital Universitario de Canarias, Santa Cruz de Tenerife, 38320, Spain 2 Intensive Care Unit, Hospital Universitario Nuestra Señora Candelaria, Santa Cruz de Tenerife, 38010, Spain 3 Department of Surgery, Hospital Universitario Nuestra Señora de Candelaria, Santa Cruz de Tenerife, 38010, Spain 4 Laboratory Department, Hospital Universitario de Canarias, San Cristóbal de La Laguna, 38320, Spain 5 Department of Digestive, Hospital Universitario Nuestra Señora de Candelaria, Santa Cruz de Tenerife, 38010, Spain 6 Research Unit, Hospital Universitario de Canarias, San Cristóbal de La Laguna, 38320, Spain 7 Transplant Unit, Hospital Universitario Nuestra Señora Candelaria, Santa Cruz de Tenerife, 38010, Spain Correspondence to: Leonardo Lorente, email: lorentemartin@msn.com Keywords: substance P; hepatocellular carcinoma; liver transplantation; mortality; outcome Abbreviations: AFP: alpha-fetoprotein; AUC: area under curve; HCC: hepatocellular carcinoma; LT: liver transplantation; MELD: model for end-stage liver disease Received: December 12, 2017 Accepted: March 23, 2018 Published: April 20, 2018 ABSTRACT Purpose: Substance P is a tachykinins family member with inflammatory effects. Higher circulating levels of substance P have been found in patients with liver diseases and in patients with higher severity of liver diseases. The objective of this study was to determine whether serum levels of substance P levels, prior to liver transplantation (LT) for hepatocellular carcinoma (HCC) are associated with one-year LT mortality. Material and Methods: In this observational retrospective unicenter study were included patients with LT for HCC. Serum levels of substance P were measured before LT. The end-point of the study was one-year mortality after LT. Results: We found that one-year survivor patients ( n = 127) showed a lower age in liver donors ( p = 0.03) and lower levels of serum substance P levels ( p = 0.003) than non-survivor patients ( n = 15). Logistic regression analysis showed that serum levels of substance P (levels) were associated with one-year mortality (Odds Ratio = 1.011; 95% CI = 1.004–1.018; p = 0.002) controlling for the age of the LT donor. Conclusions: We believe that our study is the first study reporting data on circulating levels of substance P previously to LT for HCC, and an association between elevated levels of serum substance P before LT and mortality during the first year of LT.