Produção Nacional
Revisado por pares
Insulin, Insulin Receptor and Insulin-Like Growth Factor-I Receptor on the Human Ocular Surface
2002; Springer Nature; Linguagem: Inglês
10.1007/978-1-4615-0717-8_85
ISSN2214-8019
AutoresEduardo Melani Rocha, Daniel A. Cunha, Everardo M. Carneiro, Antônio C. Boschero, Mário J.A. Saad, Lı́cio A. Velloso,
Tópico(s)Corneal surgery and disorders
ResumoInsulin, a 7,000 Da protein, known as "the most potent anabolic hormone", is produced and secreted by the pancreatic ß-cells and exerts metabolic and mitogenic effects in several target tissues.1,2 The presence of insulin in the cerebrospinal liquid has been recognized for many years and the role of insulin in the central nervous system is currently under intense investigation.3–5 Secreted fluids such as milk and saliva are also known to contain insulin, that may play important roles in the metabolism and growth of those exocrine glands.6'7 In addition, topical insulin therapy has been considered for corneal wound healing promotion and diabetes mellitus treatment.8–10
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