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Spontaneous lymphocyte transformation in chronic lymphocytic leukaemia.

1977; National Institutes of Health; Volume: 28; Issue: 3 Linguagem: Inglês

Gianpietro Semenzato, G Amadori, Francesca Tosato, G. Gasparotto,

Galectins and Cancer Biology

In ten patients with CLL and in eight controls T lymphocytes were separated out by the rosetting method. The in vitro reactivity of these cells and of unseparated lymphocytes was studied in cultures without stimulants. A net increase of spontaneous lymphocyte transformation was found in the populations enriched with T cells in patients with CLL with respect to analogous populations in the controls. This increase is interpreted as a cell-mediated immunological reaction and due to T-cell sensitization towards the neoplastic B cells.