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IFN-γ and other serum cytokines in head and neck squamous cell carcinomas

2018; Pacini Editore Medicina; Volume: 38; Issue: 2 Linguagem: Inglês

10.14639/0392-100x-1530

1827-675X

Francesco Bussu, C. Graziani, Roberto Gallus, Antonio Cittadini, Jacopo Galli, Eugenio De Corso, Giovanni Di Cintio, Maddalena Corbi, Giovanni Almadori, Alma Boninsegna, Gaetano Paludetti, Alessandro Sgambato,

NF-κB Signaling Pathways

Altered immune responses have been reported in head and neck cancer, and some of these responses have been associated with poor clinicaloutcomes. A multiple-array technology platform was used to simultaneously evaluate the levels of 25 cytokines. Pre-treatment serum levelswere evaluated in 31 HNSCC patients and 6 healthy controls. The levels of 8 cytokines, specifically IL-1ra, IL-2, IL-5, IL-6, IL-8, IL-17, IFN-γand IP-10, were significantly higher in patients than in controls. Among cancer patients we observed lower levels of IFN-g and IL-7 in caseswith nodal metastases compared to those with cN0 disease. We observed increases in the levels of some serum cytokines in HNSCC patients, aswell as reductions in selected cytokines associated with regional progression. These findings provide an intriguing perspective on the developmentand validation of novel markers for follow-up evaluations and predictions of regional spreading in HNSCC patients.