Integration of DNA Methylation & Health Scores Identifies Subtypes in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
2018; Future Medicine; Volume: 10; Issue: 5 Linguagem: Inglês
10.2217/epi-2017-0150
ISSN1750-1911
AutoresWilfred C. de Vega, Lauren Erdman, Suzanne D. Vernon, Anna Goldenberg, Patrick O. McGowan,
Tópico(s)Amyotrophic Lateral Sclerosis Research
ResumoTo identify subtypes in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) based on DNA methylation profiles and health scores.DNA methylome profiles in immune cells were integrated with symptomatology from 70 women with ME/CFS using similarity network fusion to identify subtypes.We discovered four ME/CFS subtypes associated with DNA methylation modifications in 1939 CpG sites, three RAND-36 categories and five DePaul Symptom Questionnaire measures. Methylation patterns of immune response genes and differences in physical functioning and postexertional malaise differentiated the subtypes.ME/CFS subtypes are associated with specific DNA methylation differences and health symptomatology and provide additional evidence of the potential relevance of metabolic and immune differences in ME/CFS with respect to specific symptoms.
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