Portal de Periódicos da CAPES

P650Influence of fetunin-a level on progression of calcific aortic valve stenosis The COFRASA - GENERAC StudyP651Common carotid artery remodeling 1 year after aortic valve surgeryP652Low gradient aortic stenosis with preserved ejection fraction: reclassification of severity by 3D transesophageal echocardiography. P653Results of balloon aortic valvuloplasty in patients with impaired left ventricle ejection fraction.P654Burden of associated aortic regurgitation in patients with mitral …

2016; Oxford University Press; Volume: 17; Issue: suppl 2 Linguagem: Inglês

10.1093/ehjci/jew250.001

2047-2412

Naozumi Kubota, Joann Petrini, Ariana González Gómez, DS. Sorysz, JM. Monteagudo Ruiz, Eglė Tamulėnaitė, Claire Dumont, B. De Chiara, Vincenzo Polizzi, M Ali, M. Spartera, Konstantinos Stathogiannis, Bjoern Goebel, MD Mesa Rubio, Quirino Ciampi, Sylwia Wiśniowska‐Śmiałek, LE. Sade, S. Brun, Waleed Abdou Ibrahim Hamed, Sebastian Militaru, AI. Castrini, Wander Costa Santos, Ignatios Ikonomidis, DMZ David Messika-Zeitoun, Michael Ring, K. Caidahl, Eriksson Mj, JM. Monteagudo, Covadonga Fernández‐Golfín, Carlos Izurieta, R. Hinojar, A. Garcia, Eduardo Casas, A. Marco, JJ Jimenez-Nacher, JL. Zamorano, Marzena Daniec, Maciej Stąpór, Marek Tomala, Bartłomiej Nawrotek, Łukasz Rzeszutko, Paweł Kleczyński, Artur Dziewierz, Maciej Bagieński, Krzysztof Żmudka, Dariusz Dudek, Covadonga Fernández‐Golfín, D. Mesa, T. Gonzalez-Alujas, M. Sitges, Fernando Carrasco‐Chinchilla, CH. Li, A. Grande-Trillo, A. Martinez, Javier Matabuena, David Alonso‐Rodríguez, Iolanda Aquila, A González-Gómez, JL. Zamorano, Živilė Valuckienė, R. Jurkevicius, E. Galli, E. Oger, A. Hubert, C. Leclercq, Erwan Donal, S. Quattrocchi, L. Botta, F. Casadei, A. Peritore, Oriana Belli, F. Musca, Claudio Russo, C. Giannattasio, A. Moreo, ML. Lo Presti, PG. Pino, Andrea Madeo, D. Bellavia, Vitaliano Buffa, Rosario Fiorilli, Giovanni Luzi, F. Musumeci, VT. Nkomo, PA Pellikka, H.M. Connolly, CG. Scott, GS. Sandhu, D.R. Holmes, C. Rihal, KL. Greason, S V Pislaru, Marta Barletta, Francesco Ancona, I. Rosa, S. Stella, C. Marini, Matteo Montorfano, Azeem Latib, Ottavio Alfieri, A. Margonato, A. Colombo, Eustachio Agricola, K. Toutouzas, M. Drakopoulou, Archontoula Michelongona, George Latsios, Αndreas Synetos, O. Kaitozis, Fotini Mitropoulou, Styliani Brili, D. Tousoulis, Ilonka Rohm, Ali Hamadanchi, Sylvia Otto, Chul-Ho Jung, Figulla Hr, PC. Schulze, TC. Poerner, G. Gutierrez Ballesteros, C. Aristizabal Duque, M. Ruiz Ortiz, Mónica Delgado Ortega, J. Fernandez Cabeza, M. Pan Alvarez-Osorio, Amador López Granados, M. Romero Moreno, J. Suarez De Lezo Cruz-Conde, C. Carpegiani, Claudio Michelassi, Bruno Villari, E. Picano, Paweł Rubiś, Barbara Biernacka-Fijałkowska, Ewa Dziewięcka, Lusine Khachatryan, Patrycja Faltyn, Agata Leśniak‐Sobelga, Marta Hlawaty, Magdalena Kostkiewicz, P. Podolec, U. Bal, Didem Oğuz, Selma Eroğlu, Bahar Pirat, Haldun Müderrisoğlu, S. Pradel, P. Mondoly, G. Victor, P. Pascal, M. Galinier, Didier Carrié, Philippe Maury, I. Berry, Olivier Lairez, HMB Badran, RIY Yaseen, M. Yacoub, RD Adam, Adriana Mursă, M. Chivulescu, M. Rosca, Leonard Mandeş, Elena Rusu, L. Dima, Ana Gabriela Fruntelata, BA. Popescu, CD. Ginghina, R. Jurcut, IS Leren, ME. Estensen, LG Klaeboe, T. Edvardsen, KH. Haugaa, JLB Pena, IH. Sampaio, M.L. de Siqueira, MC. Alves, Sternick Eb, George Pavlidis, V. Lambadiari, F Kousathana, H. Triantafyllidi, M. Varoudi, D. Vlastos, S. Vlachos, George Dimitriadis, J. Lekakis,

Infective Endocarditis Diagnosis and Management

Background. In recent years, pathophysiology of aortic stenosis (AS) has been considered as a possibly active inflammatory process, but its determinants remain unclear. Calcium tissue deposition observed in dilaysis patients have been linked to low level of Fetuin-A, a powerful inhibitor of ectopic calcification. It is thus suspected to play a role in development of aortic stenosis. Purpose. To assess correlation between Fetuin-A level and AS progression in a prospective cohort of AS patients, COFRASA (clinicalTrial.gov_number_NCT00338676) and GENERAC (clinicalTrial.gov_number_NCT00647088). Methods. A comprehensive clinical evaluation and Fetuin-A plasma level measurement was performed at baseline. AS severity was evaluated at baseline and yearly thereafter using echocardiography (mean pressure gradient (MPG)) and computed tomography (degree of aortic valve calcification or AVC). Annual progression was calculated as [(final measurement - baseline measurement)/follow-up duration] for both MPG and AVC measurements. Results. We enrolled 296 patients with at least 1 year of follow-up. Mean age was 74±10 years, 217 (73%) were men. Mean Fetuin-A level was 0.55±0.15 g/L. After a mean follow-up of 3.0±1.7 years, no correlation was found between AS progression and Fetuin-A level, using either MPG (r=0.015, p=0.82) or AVC (r=0.014, p=0.82). This was also true when comparing patients with lower level of Fetuin-A (≤0.53 g/L, the median in our cohort) with patients with higher level(+3±5 mmHg/year (median 2, [0-5] vs +4±4 mmHg/year (median 2, [1-6]) p=0.06, and +205±290 AUC/year (median 122, [32-269]) vs +240±310 AUC/year (median 145, [50-313], p=0.24). This was true also after adjustment for baseline severity and valve antomy. Conclusions. In our prospective cohortot of AS patients we found no impact of Fetuin-A on both hemodynamic and anatomic AS progression. Despite strong capacity to inhibit ectopic calcium deposition, Fetuin-A plasma level seems to have minor influence on AS progression.