Oral Tranexamic Acid for the Treatment of Melasma: A Review
2018; Lippincott Williams & Wilkins; Volume: 44; Issue: 6 Linguagem: Inglês
10.1097/dss.0000000000001518
ISSN1524-4725
AutoresHarini Rajgopal Bala, Senhong Lee, Celestine Wong, Amit G. Pandya, Michelle Rodrigues,
Tópico(s)Hair Growth and Disorders
ResumoMelasma is a common acquired disorder of hyperpigmentation that commonly affects those with skin of color. Tranexamic acid (TXA) is a novel treatment for melasma that has a multimodal mechanism of action.To provide a comprehensive review of the literature regarding the evidence on the mode of action, safety profile, and efficacy of TXA in the treatment of melasma.The literature was searched for publications on TXA in the treatment of melasma using MEDLINE, Scopus, and Google Scholar.Oral TXA has clearly demonstrated the efficacy for melasma in Asian skin, even in low doses (e.g., 500 mg daily) over short periods (8-12 weeks). It is also a safe therapeutic option, which is easy to administer with few and mild side effects. Studies have shown that TXA does not increase the thromboembolic risk, although patients should be screened carefully for contraindications and risk factors prior to commencement of the therapy.Oral TXA is a safe and efficacious treatment for refractory melasma. It should be considered in cases that are unresponsive to topical hydroquinone and combination topical therapy over a period of approximately 12 weeks and without contraindications to oral TXA.
Referência(s)