Double-layered microsphere based dual growth factor delivery system for guided bone regeneration
2018; Royal Society of Chemistry; Volume: 8; Issue: 30 Linguagem: Inglês
10.1039/c8ra02072h
ISSN2046-2069
AutoresC. F. Xu, Jia Xu, Lan Xiao, Zhihao Li, Yin Xiao, Matthew S. Dargusch, Chang Lei, Yan He, Qingsong Ye,
Tópico(s)Advanced Drug Delivery Systems
ResumoMicrosphere based drug delivery systems show great advantages for tissue engineering. However, it is still a big challenge to fabricate microspheres with capability in delivering and controlled releasing multiple growth factors. In the present study, double-layered microspheres consisting of an inner-layer of small core particles and an outer-layer of big shell particles were developed to sequentially release cell homing factors (SDF-1) and osteoinductive growth factors (BMP-2) for bone regeneration.
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