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Novel Approach to Estimate Osteoarthritis Progression: Use of the Reliable Change Index in the Evaluation of Joint Space Loss

2018; Wiley; Volume: 71; Issue: 2 Linguagem: Inglês

10.1002/acr.23596

2151-4658

Camille Parsons, Andrew Judge, K.M. Leyland, Olivier Bruyère, Florence Petit Dop, Roland Chapurlat, Jean‐Yves Reginster, Mark H. Edwards, Elaine Dennison, Cyrus Cooper, Hazel Inskip, Jean‐Yves Reginster, C. Christiansen, Pierre Delmas, H K Genant, J. Zacher, Nicholas Bellamy, C. Speirs, Gérard Bréart, O. Meyer, D. Gensburger, M. Arlot, Jean‐Paul Roux, Rita Deroisy, Philip N. Sambrook, Burkhard F. Leeb, Ann Verbruggen, W. Bensen, Tomas Hala, M. Holm‐Bentzen, Ivo Valter, Xavier Chevalier, B. Swoboda, S. Adámi, M. Kloppenburg, Edita Grazuleviciūte, J Badurski, Jaime Branco, E L Nasonov, Federico Navarro, Tim D. Spector, L Barnsley, Sharon M. Hall, Graeme Jones, A. Klestov, Lyn March, Peter Nash, E. Romas, R. Will, Ludwig Erlacher, Franziska Leeb, Heinrich Resch, Franz Rainer, Omid Zamani, Thierry Appelboom, J.-P. Devogelaer, A. Kvasz, F. Raeman, A. D. Beaulieu, Judith C. Brown, Alfred Cividino, Franck Morin, W. P. Olszynski, J. P. Raynauld, J. C. Thorne, Karel Pavelká, Peter Alexandersen, Hans Christian Hoeck, M. Holm‐Bentzen, Pia Lundqvist, Laurène Ben Aim, P. Audouy, Patricia Beaunier, C. L. Benhamou, F. Berenbaum, E. Chabaud, M. Cohen-Solal, D. Delbecq, L Euller-Ziegler, Patrice Fardellone, Pascal Hilliquin, E. Jacquety, Nicole Jude, D. Lechevalier, Jacques Mouchet, Pascal Richette, E. De Sainte Lorette, T. Schaeverbeke, Alissa Sebbah, E. Vignot, T. Brabant, G. R. Burm-Ester, Joachim Grifka, Paul-Heinrich Mueller, Giovanna Bianchi, Walter Grassi, Luigi Di Matteo, V. Modena, Ombretta Di Munno, S. Ortolani, Leonardo Punzi, M. Zangari, L.D. Roorda, P. L. C. M. van Riel, E. J. Czerwiński, Andrzej Górecki, Witold Tłustochowicz, J. Canas da Silva, José António Melo Gomes, Leandro Macêdo Miranda, F. Radulescu, L I Alexeeva, A. V. Orlov-Morozov, E G Pikhlak, Valery G Pilyaev, N. A. Shostak, Е. Шмидт, N. V. Zagorodniy, L. Arboleya Rodriguez, Pablo Ruíz, Eugenio Chamizo Carmona, Eduardo Collantes‐Estévez, Gabriel Herrero‐Beaumont, E. Martín Mola, A. Moreno, Antonio Naranjo, Federico Navarro Sarabia, J. M. Padrino, Cynthia Jimena Palacios, Arturo Rodríguez de la Serna, Jose Andrés Román Ivorra, A. Torrijos, Essam Eldin Ahmed Abdulhakim, Nigel Arden, Fraser Birrell, Hugh Donnachie, William D. Fraser, Richard Keen, Raul Sarmiento, Mike Stone, Sekoia Study,

Spondyloarthritis Studies and Treatments

Osteoarthritis-related changes in joint space measurements over time are small and sensitive to measurement error. The Reliable Change Index (RCI) determines whether the magnitude of change observed in an individual can be attributed to true change. This study aimed to examine the RCI as a novel approach to estimating osteoarthritis progression.Data were from 167 men and 392 women with knee osteoarthritis (diagnosed using the American College of Rheumatology criteria) randomized to the placebo arm of the 3-year Strontium Ranelate Efficacy in Knee Osteoarthritis trial (SEKOIA) and assessed annually. The RCI was used to determine whether the magnitude of change in joint space width (JSW) on radiographs between study years was likely to be true or due to measurement error.Between consecutive years, 57-69% of participants had an apparent decrease (change <0) in JSW, while 31-43% of participants had annual changes indicating improvement in JSW. The RCI identified JSW decreases in only 6.0% of patients between baseline and year 1, and in 4.5% of patients between the remaining study years. The apparent increases in JSW were almost eliminated between baseline and year 1, and between years 1 and 2 only 1.3% of patients had a significant increase, dropping to 0.9% between years 2 and 3.The RCI provides a method to identify change in JSW, removing many apparent changes that are likely to be due to measurement error. This method appears to be useful for assessing change in JSW from radiographs in clinical and research settings.