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BIBTEX RIS

Cofilin-1 levels and intracellular localization are associated with melanoma prognosis in a cohort of patients

2018; Impact Journals LLC; Volume: 9; Issue: 35 Linguagem: Inglês

10.18632/oncotarget.25303

ISSN

1949-2553

Autores

Candelaria Bracalente, Adriana Raquel Rinflerch, Irene L. Ibañez, Francisco Manuel Martínez García, Victoria Volonteri, Gastón Galimberti, Fábio Klamt, Hebe Durán,

Tópico(s)

Cutaneous Melanoma Detection and Management

Resumo

// Candelaria Bracalente 1, 2 , Adriana R. Rinflerch 3 , Irene L. Ibañez 1, 2 , Francisco M. García 4 , Victoria Volonteri 5 , Gastón N. Galimberti 3 , Fabio Klamt 6 and Hebe Durán 1, 2, 4 1 Gerencia de Investigación y Aplicaciones, Comisión Nacional de Energía Atómica, (B1650KNA) San Martín, Buenos Aires, Argentina 2 Consejo Nacional de Investigaciones Científicas y Técnicas, (C1425FQB) CABA, Buenos Aires, Argentina 3 Dermatología Experimental, Servicio de Dermatología, Hospital Italiano de Buenos Aires, (C1199ABB) CABA, Buenos Aires, Argentina 4 Escuela de Ciencia y Tecnología, Universidad Nacional de San Martín, Campus Miguelete, (B1650HMP) San Martín, Buenos Aires, Argentina 5 Servicio de Anatomía Patológica, Hospital Italiano de Buenos Aires, (C1199ABB) CABA, Buenos Aires, Argentina 6 Laboratório de Bioquímica Celular, Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, (90035 003), Porto Alegre, Brazil Correspondence to: Hebe Durán, email: hduran@cnea.gov.ar Keywords: cofilin-1; melanoma; metastasis; nuclear localization; prognosis Received: August 30, 2017 Accepted: April 05, 2018 Published: May 08, 2018 ABSTRACT Melanoma is an aggressive cancer with highly metastatic ability. We propose cofilin-1, a key protein in the regulation of actin dynamics and migration, as a prognostic marker. We determined cofilin-1 levels in a retrospective cohort of patients with melanomas and benign lesions of melanocytes (nevi) by immunohistochemistry. Higher cofilin-1 levels were found in malignant melanoma (MM) with Breslow Index (BI)>2 vs MM with BI 2 vs MM with BI<2, MIS and nevi. In conclusion, an association of cofilin-1 levels with malignant features and an inverse correlation with survival were demonstrated. Moreover, this study suggests that not only the higher levels of cofilin-1, but also its nuclear localization can be proposed as marker of worse outcome of patients with melanoma.

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