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Scientific Opinion on the risks for public and animal health related to the presence of citrinin in food and feed

2012; Wiley; Volume: 10; Issue: 3 Linguagem: Inglês

10.2903/j.efsa.2012.2605

ISSN

1831-4732

Tópico(s)

Identification and Quantification in Food

Resumo

EFSA JournalVolume 10, Issue 3 2605 OpinionOpen Access Scientific Opinion on the risks for public and animal health related to the presence of citrinin in food and feed EFSA Panel on Contaminants in the Food Chain (CONTAM), EFSA Panel on Contaminants in the Food Chain (CONTAM)Search for more papers by this author EFSA Panel on Contaminants in the Food Chain (CONTAM), EFSA Panel on Contaminants in the Food Chain (CONTAM)Search for more papers by this author First published: 23 March 2012 https://doi.org/10.2903/j.efsa.2012.2605Citations: 99 Panel members: Jan Alexander, Diane Benford, Alan Boobis, Sandra Ceccatelli, Bruce Cottrill, Jean-Pierre Cravedi, Alessandro Di Domenico, Daniel Doerge, Eugenia Dogliotti, Lutz Edler, Peter Farmer, Metka Filipič, Johanna Fink-Gremmels, Peter Fürst, Thierry Guérin, Helle Katrine Knutsen, Miroslav Machala, Antonio Mutti, Martin Rose, Josef Schlatter and Rolaf van Leeuwen Correspondence: [email protected] Acknowledgement: The Panel wishes to thank the members of the Working Group on Aspergillus toxins: Josef Böhm, Sarah De Saeger, Lutz Edler, Johanna Fink-Gremmels, Peter Mantle, Maja Peraica, Rudolf Stetina and Terry Vrabcheva for the preparatory work on this scientific opinion and EFSA staff: Katleen Baert, Alessandro Carletti, Gina Cioacata, Elena Scaravelli and Natalie Thatcher for the support provided to this scientific opinion. Adoption date: 2 March 2012 Published date: 23 March 2012 Question number: EFSA-Q-2010-01009 On request from: European Commission AboutPDF ToolsExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Abstract The European Food Safety Authority (EFSA) was asked by the European Commission to deliver a scientific opinion on the health risks from citrinin in food and feed. Citrinin is a mycotoxin produced by several species of the genera Aspergillus, Penicillium and Monascus and occurs mainly in stored grains. The available occurrence data were not adequate to carry out a dietary exposure assessment. Citrinin is nephrotoxic and a no-observed-adverse-effect level (NOAEL) of 20 µg/kg body weight (b.w.) per day was identified from a 90-day study in rats. Due to the limitations and uncertainties in the database, the derivation of a health-based guidance value was not considered appropriate but a level of no concern for nephrotoxicity of 0.2 µg/kg b.w. per day was determined. Based on the available data a concern for genotoxicity and carcinogenicity could not be excluded at the level of no concern for nephrotoxicity. In the absence of adequate exposure data, characterisation of the risk of citrinin as a food contaminant was based on the estimate of the citrinin concentrations in grains and grain-based products that would result in an exposure equal to the level of no concern for nephrotoxicity. For high consuming toddlers, other children and adults this citrinin concentration is between 9 and 53 µg citrinin/kg and between 19 and 100 µg citrinin/kg for average consumers, respectively. 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