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Long-term viability and function of transplanted islets macroencapsulated at high density are achieved by enhanced oxygen supply

2018; Nature Portfolio; Volume: 8; Issue: 1 Linguagem: Inglês

10.1038/s41598-018-23862-w

2045-2322

Yoav Evron, Clark K. Colton, Barbara Ludwig, Gordon C. Weir, Baruch Zimermann, Shiri Maimon, Tova Neufeld, Nurit Shalev, Tali Goldman, Assaf Leon, Karina Yavriyants, Noa Shabtay, Tania Rozenshtein, Dimitri Azarov, Amanda R. DiIenno, Anja Steffen, Paul de Vos, Stefan R. Bornstein, Uriel Barkai, Avi Rotem,

Cannabis and Cannabinoid Research

Transplantation of encapsulated islets can cure diabetes without immunosuppression, but oxygen supply limitations can cause failure. We investigated a retrievable macroencapsulation device wherein islets are encapsulated in a planar alginate slab and supplied with exogenous oxygen from a replenishable gas chamber. Translation to clinically-useful devices entails reduction of device size by increasing islet surface density, which requires increased gas chamber pO