Produção Nacional
Revisado por pares
Long Non-Coding RNAs in Multifactorial Diseases: Another Layer of Complexity
2018; Multidisciplinary Digital Publishing Institute; Volume: 4; Issue: 2 Linguagem: Inglês
10.3390/ncrna4020013
ISSN2311-553X
AutoresGabriel Adelman Cipolla, Jaqueline Carvalho de Oliveira, Amanda Salviano‐Silva, Sara Cristina Lobo‐Alves, Débora S. Lemos, Luana Ramos de Oliveira, Tayana Shultz Jucoski, Carolina Mathias, Gabrielle Araújo Pedroso, Érika Pereira Zambalde, Daniela Fiori Gradia,
Tópico(s)RNA modifications and cancer
ResumoMultifactorial diseases such as cancer, cardiovascular conditions and neurological, immunological and metabolic disorders are a group of diseases caused by the combination of genetic and environmental factors. High-throughput RNA sequencing (RNA-seq) technologies have revealed that less than 2% of the genome corresponds to protein-coding genes, although most of the human genome is transcribed. The other transcripts include a large variety of non-coding RNAs (ncRNAs), and the continuous generation of RNA-seq data shows that ncRNAs are strongly deregulated and may be important players in pathological processes. A specific class of ncRNAs, the long non-coding RNAs (lncRNAs), has been intensively studied in human diseases. For clinical purposes, lncRNAs may have advantages mainly because of their specificity and differential expression patterns, as well as their ideal qualities for diagnosis and therapeutics. Multifactorial diseases are the major cause of death worldwide and many aspects of their development are not fully understood. Recent data about lncRNAs has improved our knowledge and helped risk assessment and prognosis of these pathologies. This review summarizes the involvement of some lncRNAs in the most common multifactorial diseases, with a focus on those with published functional data.
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