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Tenecteplase versus Alteplase before Thrombectomy for Ischemic Stroke

2018; Massachusetts Medical Society; Volume: 378; Issue: 17 Linguagem: Inglês

10.1056/nejmoa1716405

1533-4406

Bruce Campbell, Peter Mitchell, Leonid Churilov, Nawaf Yassi, Timothy Kleinig, Richard Dowling, Bernard Yan, Steven Bush, Helen M. Dewey, Vincent Thijs, Rebecca Scroop, Marion Simpson, Mark Brooks, Hamed Asadi, Teddy Y. Wu, Darshan Shah, Tissa Wijeratne, Timothy Ang, Ferdinand Miteff, Christopher Levi, Edrich Rodrigues, Henry Zhao, Patrick Salvaris, Carlos García-Esperón, Peter Bailey, Henry E. Rice, Laetitia de Villiers, Helen Brown, Kendal Redmond, David Leggett, John Fink, Wayne Collecutt, Andrew Wong, Claire Muller, Alan Coulthard, Ken Mitchell, John Clouston, Kate Mahady, Deborah Field, Henry Ma, Thanh G. Phan, Winston Chong, Ronil V. Chandra, Lee‐Anne Slater, Martín Krause, Timothy Harrington, Kenneth Faulder, Brendan Steinfort, Christopher F. Bladin, Gagan Sharma, Patricia Desmond, Mark Parsons, Geoffrey A. Donnan, Stephen M. Davis,

Stroke Rehabilitation and Recovery

Intravenous infusion of alteplase is used for thrombolysis before endovascular thrombectomy for ischemic stroke. Tenecteplase, which is more fibrin-specific and has longer activity than alteplase, is given as a bolus and may increase the incidence of vascular reperfusion.