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Cytosine modifications exhibit circadian oscillations that are involved in epigenetic diversity and aging

2018; Nature Portfolio; Volume: 9; Issue: 1 Linguagem: Inglês

10.1038/s41467-018-03073-7

2041-1723

Gabriel Oh, Sasha B. Ebrahimi, Matthew Carlucci, Aiping Zhang, Akhil Nair, Daniel E. Groot, Viviane Labrie, Peixin Jia, Edward Oh, Richie Jeremian, Miki Susic, Tenjin C. Shrestha, Martin R. Ralph, Juozas Gordevičius, Karolis Koncevičius, Artūras Petronis,

Genetics, Aging, and Longevity in Model Organisms

Circadian rhythmicity governs a remarkable array of fundamental biological functions and is mediated by cyclical transcriptomic and proteomic activities. Epigenetic factors are also involved in this circadian machinery; however, despite extensive efforts, detection and characterization of circadian cytosine modifications at the nucleotide level have remained elusive. In this study, we report that a large proportion of epigenetically variable cytosines show a circadian pattern in their modification status in mice. Importantly, the cytosines with circadian epigenetic oscillations significantly overlap with the cytosines exhibiting age-related changes in their modification status. Our findings suggest that evolutionary advantageous processes such as circadian rhythmicity can also contribute to an organism's deterioration.