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Inhibition of the essential oil from Chenopodium ambrosioides L. and α-terpinene on the NorA efflux-pump of Staphylococcus aureus

2018; Elsevier BV; Volume: 262; Linguagem: Inglês

10.1016/j.foodchem.2018.04.040

1873-7072

Cícera Datiane de Morais Oliveira‐Tintino, Saulo Relison Tintino, Paulo W. Limaverde, Fernando Gomes Figueredo, Fábia F. Campina, Francisco Assis Bezerra da Cunha, Roger Henrique Sousa da Costa, Pedro Silvino Pereira, Luciene Ferreira de Lima, Yedda Maria Lobo Soares de Matos, Henrique Douglas Melo Coutinho, José P. Siqueira-Júnior, Valdir de Queiroz Balbino, Teresinha Gonçalves da Silva,

Psidium guajava Extracts and Applications

This study was carried out to test the essential oil from C. ambrosioides leaves and its main constituent, α-Terpinene, in an antibacterial activity assay. As well, it was evaluated ability reduce resistance to norfloxacin and ethidium bromide was compared the Staphylococcus aureus 1199B whith 1199 wild type strain. The MIC of the C. ambrosioides essential oil and α-Terpinene were determined by microdilution method. The MIC of the essential oil and α-Terpinene presented a value ≥ 1024 μg/mL. However, when associated with antibacterials, the essential oil from C. ambrosioides leaves significantly reduced the MIC of antibiotics and ethidium bromide, characterizing an efflux pump inhibition. The C. ambrosioides essential oil, despite having no direct antibacterial activity against the S. aureus 1199B strain, showed a potentiating action when associated with antibacterial agents, this being attributed to an inhibition of efflux pumps.