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Long-term serum platinum changes and their association with cisplatin-related late effects in testicular cancer survivors

2018; Taylor & Francis; Volume: 57; Issue: 10 Linguagem: Inglês

10.1080/0284186x.2018.1473641

1651-226X

Line V. Hjelle, Per Ole M. Gundersen, Ragnhild Hellesnes, Mette Sprauten, Marianne Brydøy, Torgrim Tandstad, Tom Wilsgaard, Sophie D. Fosså, Jan Oldenburg, Roy M. Bremnes, Hege Sagstuen Haugnes,

Glioma Diagnosis and Treatment

Background: The long-term toxicities after cisplatin-based chemotherapy (CBCT) reveal a remarkable inter-individual variation among testicular cancer survivors (TCSs). Therefore, we assessed long-term platinum (Pt) changes and their associations with CBCT-related late effects in TCSs.Material and methods: In 77 TCSs treated with CBCT from 1984 to 1990, blood samples for analyses of Pt and a questionnaire including self-reported neuro- and ototoxicity (NTX) symptoms were collected during two follow-up surveys at median 12 (Survey I; SI) and 20 (Survey II; SII) years after treatment. Information about second cancers after SII was retrieved from the Norwegian Cancer Registry.Results: A larger Pt decline from SI to SII was associated with a decreased risk of a second cancer diagnosis (HR 0.78, 95% CI 0.62–0.99 per 10 ng/L/year), and worsening of paresthesias in hands (OR 1.98, 95% CI 1.09–3.59 per 10 ng/L/year) and tinnitus (OR 1.51, 95% CI 1.01–2.27 per 10 ng/L/year).Conclusion: In summary, we found a significant association between a larger Pt decline and a reduced risk of second cancers and deterioration of paresthesias in hands and tinnitus.