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Cardiac repolarization and depolarization in people with Type 1 diabetes with normal ejection fraction and without known heart disease: a case‐control study

2018; Wiley; Volume: 35; Issue: 10 Linguagem: Inglês

10.1111/dme.13689

1464-5491

Jonas L. Isaksen, Claus Graff, Christina Ellervik, Jan Skov Jensen, Peter Rossing, Jørgen K. Kanters, Magnus T. Jensen,

Cardiac Arrhythmias and Treatments

Abstract Aims To investigate depolarization and repolarization durations in people with Type 1 diabetes, including the relationship to age. Methods 855 persons with Type 1 diabetes without known heart disease were included and matched with 1710 participants from a general population study. Clinical examinations, questionnaires and biochemistry were assessed. A 10‐second 12‐lead ECG was performed and analysed digitally. Results QT c was longer in people with Type 1 diabetes compared to controls (414±16 vs. 411±19 ms, P <0.001), and particularly so in young people with Type 1 diabetes. The fully adjusted increase was 13.8 ms (95% confidence interval ( CI ): 8.6–19.0 ms, P <0.001) at age 20 years and 3.4 ms ( CI : 1.5–5.3 ms, P <0.001) at age 40 years. The rate‐corrected QRS c was increased in people with Type 1 diabetes (97±11 vs. 95±11 ms, P <0.001) and was age‐independent ( P =0.5). JT c was increased in the young people with Type 1 diabetes (10.7 ms ( CI : 5.4–16.0 ms, P <0.001) at age 20 years), but not in older people with Type 1 diabetes (interaction age‐diabetes, P <0.01). Conclusions For people with Type 1 diabetes, cardiac depolarization is increased at all ages, whereas repolarization is increased only relatively in young people with Type 1 diabetes. Hence, young people with Type 1 diabetes may be more prone to ventricular arrhythmias. The findings contribute to the understanding of sudden cardiac death in young people with Type 1 diabetes.