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Prospective Randomized Trial Comparing Embryo Transfers of Cases with and without Catheter Rotation during Its Withdrawal

2018; Karger Publishers; Volume: 83; Issue: 4 Linguagem: Inglês

10.1159/000489493

1423-002X

Çiğdem Yayla Abide, Enis Özkaya, İlhan Şanverdi, Evrim Bostancı Ergen, Meryem Kürek Eken, Belgin Devranoğlu, Bülent Emre Bilgiç, Çetin Kılıççı, S Eser,

Prenatal Screening and Diagnostics

<b><i>Objective:</i></b> To compare embryo transfer (ET) technique based on catheter rotation during its withdrawal in cases with unexplained infertility in a prospective, randomized trial (NCT03097042). <b><i>Methods:</i></b> Two hundred intracytoplasmic sperm injection (ICSI) patients undergoing ET with cleaving or blastocyst-stage fresh embryos were randomized into 2 groups: cases with (<i>n</i> = 100), and without (<i>n</i> = 100) catheter rotation during its withdrawal. Groups were matched for age and some clinical parameters. A soft catheter was used to transfer a single embryo with catheter rotation during its withdrawal in the study group and without rotation in the control. The use of a stiff catheter or tenaculum was not needed in any case. Groups were compared in terms of cycle characteristics and clinical pregnancy rates. <b><i>Results:</i></b> Pregnancy rate was significantly higher in the study group (41 vs. 26%, <i>p =</i> 0.04). Clinical pregnancy rate was also significantly higher in the study group (39 vs. 25%, OR 1.9 [1.1–3.5], <i>p =</i> 0.05). On the other hand, the ongoing pregnancy rate was similar between the 2 groups (33 vs. 23%, <i>p</i> = 0.2). <b><i>Conclusion:</i></b> Catheter rotation during its withdrawal may be associated with increased pregnancy and clinical pregnancy rates; however, the difference in ongoing pregnancy rates did not reach statistical significance.