Evolving Complexity in Hemophilia Management
2018; Elsevier BV; Volume: 65; Issue: 3 Linguagem: Inglês
10.1016/j.pcl.2018.01.004
ISSN1557-8240
Autores Tópico(s)Blood Coagulation and Thrombosis Mechanisms
ResumoRapid expansion of therapeutic options have increased the complexity of hemophilia care. Previously, on-demand therapy aimed to reduce morbidity and early mortality; however, now aggressive prophylaxis, particularly in children, encourages an active lifestyle. Accurate diagnosis, recognition of early threats to musculoskeletal health, and optimization of therapy are critical for both males and females affected by hemophilia. The diversity of emerging hemophilia therapies, from modified factor protein concentrates, to gene therapy, to nonfactor hemostatic strategies, provide an exciting opportunity to target unmet needs in the bleeding disorder community.
Referência(s)