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The wide utility of rabbits as models of human diseases

2018; Springer Nature; Volume: 50; Issue: 5 Linguagem: Inglês

10.1038/s12276-018-0094-1

2092-6413

Pedro J. Esteves, Joana Abrantes, Hanna-Mari Baldauf, Lbachir BenMohamed, Yuxing Chen, Neil D. Christensen, Javier González‐Gallego, Lorenzo Giacani, Jiafen Hu, Gilla Kaplan, Oliver T. Keppler, Katherine L. Knight, Xiang‐Peng Kong, Dennis Lanning, Jacques Le Pendu, Ana Lemos de Matos, Jia Liu, Shuying Liu, Ana M. Lopes, Shan Lu, Sheila A. Lukehart, Yukari C. Manabe, Fabiana Neves, Grant McFadden, Ruimin Pan, Xuwen Peng, Patrícia de Sousa-Pereira, Ana Pinheiro, Masmudur M. Rahman, Natalie Ruvoën-Clouet, Selvakumar Subbian, María J. Tuñón, Wessel van der Loo, Michael Vaine, Laura E. Via, Shixia Wang, Rose G. Mage,

Clostridium difficile and Clostridium perfringens research

Studies using the European rabbit Oryctolagus cuniculus contributed to elucidating numerous fundamental aspects of antibody structure and diversification mechanisms and continue to be valuable for the development and testing of therapeutic humanized polyclonal and monoclonal antibodies. Additionally, during the last two decades, the use of the European rabbit as an animal model has been increasingly extended to many human diseases. This review documents the continuing wide utility of the rabbit as a reliable disease model for development of therapeutics and vaccines and studies of the cellular and molecular mechanisms underlying many human diseases. Examples include syphilis, tuberculosis, HIV-AIDS, acute hepatic failure and diseases caused by noroviruses, ocular herpes, and papillomaviruses. The use of rabbits for vaccine development studies, which began with Louis Pasteur's rabies vaccine in 1881, continues today with targets that include the potentially blinding HSV-1 virus infection and HIV-AIDS. Additionally, two highly fatal viral diseases, rabbit hemorrhagic disease and myxomatosis, affect the European rabbit and provide unique models to understand co-evolution between a vertebrate host and viral pathogens. Rabbits offer a powerful complement to rodents as a model for studying human immunology, disease pathology, and responses to infectious disease. A review from Pedro Esteves at the University of Porto, Portugal, Rose Mage of the National Institute of Allergy and Infectious Disease, Bethesda, USA and colleagues highlights some of the areas of research where rabbits offer an edge over rats and mice. Rabbits have a particularly sophisticated adaptive immune system, which could provide useful insights into human biology and produce valuable research and clinical reagents. They are also excellent models for studying - infectious diseases such as syphilis and tuberculosis, which produce pathology that closely resembles that of human patients. Rabbit-specific infections such as myxomatosis are giving researchers insights into how pathogens and hosts can shape each other's evolution.