Portal de Periódicos da CAPES

Identification of novel mutational drivers reveals oncogene dependencies in multiple myeloma

2018; Elsevier BV; Volume: 132; Issue: 6 Linguagem: Inglês

10.1182/blood-2018-03-840132

1528-0020

Brian A. Walker, Konstantinos Mavrommatis, Christopher P. Wardell, Cody Ashby, Michael Bauer, Faith E. Davies, Adam Rosenthal, Hongwei Wang, Pingping Qu, Antje Hoering, Mehmet Samur, Fadi Towfic, María Ortiz, Erin Flynt, Zhinuan Yu, Zhihong Yang, Dan Rozelle, John C. Obenauer, Matthew Trotter, Daniel Auclair, Jonathan J. Keats, Niccolò Bolli, Mariateresa Fulciniti, Raphaël Szalat, Philippe Moreau, Brian G.M. Durie, A. Keith Stewart, Hartmut Goldschmidt, Marc S. Raab, Hermann Einsele, Pieter Sonneveld, Jesús F. San Miguel, Sagar Lonial, Graham Jackson, Kenneth C. Anderson, Hervé Avet‐Loiseau, Nikhil Munshi, Anjan Thakurta, Gareth J. Morgan,

Cancer Genomics and Diagnostics

Key Points Using the largest set of patients with newly diagnosed myeloma, we identified 63 mutated driver genes. We identified oncogenic dependencies, particularly relating to primary translocations, indicating a nonrandom accumulation of genetic hits.