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Mass cytometry of Hodgkin lymphoma reveals a CD4+ regulatory T-cell–rich and exhausted T-effector microenvironment

2018; Elsevier BV; Volume: 132; Issue: 8 Linguagem: Inglês

10.1182/blood-2018-04-843714

1528-0020

Fathima Zumla Cader, Ron C.J. Schackmann, Xihao Hu, Kirsty Wienand, Robert Redd, Bjoern Chapuy, Jing Ouyang, Nicole Paul, Evisa Gjini, Mikel Lipschitz, Philippe Armand, David Wu, Jonathan R. Fromm, Donna Neuberg, X. Shirley Liu, Scott J. Rodig, Margaret A. Shipp,

T-cell and B-cell Immunology

Key Points Newly diagnosed primary cHLs have a concomitant increase in CD4+ Th1-polarized Tregs and differentiated Teffs. Primary cHLs exhibit 2 major complementary bases of immunosuppression: likely exhausted PD-1+ Th1 Teffs and active PD-1− Th1 Tregs.