Portal de Periódicos da CAPES

Artigo Acesso aberto Produção Nacional Revisado por pares

BIBTEX RIS

Spherical neutral gold nanoparticles improve anti-inflammatory response, oxidative stress and fibrosis in alcohol-methamphetamine-induced liver injury in rats

2018; Elsevier BV; Volume: 548; Issue: 1 Linguagem: Inglês

10.1016/j.ijpharm.2018.06.008

1873-3476

Thaís Gomes de Carvalho, Vinícius Barreto Garcia, Aurigena Antunes de Araújo, Luiz H. S. Gasparotto, Heloiza Silva, Gerlane Coelho Bernardo Guerra, Emílio de Castro Miguel, Renata Ferreira de Carvalho Leitão, Deiziane Viana da Silva Costa, Luis J. Cruz, Alan Chan, Raimundo Fernandes de Araújo Júnior,

Drug-Induced Hepatotoxicity and Protection

This study aimed to elucidate the anti-inflammatory, anti-oxidant and antifibrotic effects of gold nanoparticles (GNPs) in rats subjected to liver injury with ethanol and Methamphetamine (METH). The liver injury was induced by gavage administrations of 30% alcoholic solution (7 g/kg) once a day during 28 days, followed by METH (10 mg/kg) on the 20th and 28th days of treatment. GNPs treatment (724.96 µg/kg) during the ethanol and METH exposure was associated with reduced steatosis, hepatic cord degeneration, fibrosis and necrosis. Furthermore, there was a reduction in biochemical markers of liver damage and oxidative stress, and pro-inflammatory cytokines IL-1β and TNF-α, compared to ethanol + METH group alone. A decrease of FGF, SOD-1 and GPx-1 expression was also observed. GNPs down-regulated the activity of Kupffer cells and hepatic stellate cells affecting the profile of their pro-inflammatory cytokines, oxidative stress and fibrosis through modulation of signaling pathways AKT/PI3K and MAPK in ethanol + METH-induced liver injury in a rat model.