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BIBTEX RIS

Staphylococcus aureus enterotoxins modulate IL-22-secreting cells in adults with atopic dermatitis

2018; Nature Portfolio; Volume: 8; Issue: 1 Linguagem: Inglês

10.1038/s41598-018-25125-0

ISSN

2045-2322

Autores

Raquel Leão Orfali, Luanda Mara da Silva Oliveira, Josenilson Feitosa de Lima, Gabriel Costa de Carvalho, Yasmim Álefe Leuzzi Ramos, Nátalli Zanete Pereira, Naiura Vieira Pereira, Mariana Colombini Zaniboni, Mírian Nacagami Sotto, Alberto José da Silva Duarte, Maria Notomi Sato, Valéria Aoki,

Tópico(s)

Allergic Rhinitis and Sensitization

Resumo

Atopic dermatitis (AD) is a chronic inflammatory immune-mediated skin disease characterized by skin colonization by Staphylococcus aureus. Interleukin (IL)-22, in cooperation with IL-17, triggers antimicrobial peptide elaboration and enhances certain immunological responses. In AD, IL-22 is related to epidermal hyperplasia, keratinocyte apoptosis, and inhibition of antimicrobial peptide (AMP) production. We aimed to evaluate the impact of staphylococcal enterotoxins on the Tc22/Th22 induction in the peripheral blood of AD patients and on CD4

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