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BIBTEX RIS

Aging-Induced Biological Changes and Cardiovascular Diseases

2018; Hindawi Publishing Corporation; Volume: 2018; Linguagem: Inglês

10.1155/2018/7156435

2314-6141

James Oluwagbamigbe Fajemiroye, Luíz Carlos da Cunha, Roberto Saavedra-Rodríguez, Karla Lima Rodrigues, Lara Marques Naves, Aline A. Mourão, Elaine Fernanda da Silva, Nabofa Enivwenaye Egide Williams, José Luís Rodrigues Martins, Romes Bittencourt Nogueira de Sousa, Ana Cristina Silva Rebelo, Angela Adamsk da Silva Reis, Rodrigo da Silva Santos, Marcos L. Ferreira‐Neto, Gustavo Rodrigues Pedrino,

Mitochondrial Function and Pathology

Aging is characterized by functional decline in homeostatic regulation and vital cellular events. This process can be linked with the development of cardiovascular diseases (CVDs). In this review, we discussed aging-induced biological alterations that are associated with CVDs through the following aspects: (i) structural, biochemical, and functional modifications; (ii) autonomic nervous system (ANS) dysregulation; (iii) epigenetic alterations; and (iv) atherosclerosis and stroke development. Aging-mediated structural and biochemical modifications coupled with gradual loss of ANS regulation, vascular stiffening, and deposition of collagen and calcium often disrupt cardiovascular system homeostasis. The structural and biochemical adjustments have been consistently implicated in the progressive increase in mechanical burden and functional breakdown of the heart and vessels. In addition, cardiomyocyte loss in this process often reduces adaptive capacity and cardiovascular function. The accumulation of epigenetic changes also plays important roles in the development of CVDs. In summary, the understanding of the aging-mediated changes remains promising towards effective diagnosis, discovery of new drug targets, and development of new therapies for the treatment of CVDs.