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Guianofruits A and B from the Fruit Oil of Andiroba ( Carapa guianensis , Meliaceae) and Their Effects on LPS‐Activated NO Production

2018; Wiley; Volume: 3; Issue: 22 Linguagem: Inglês

10.1002/slct.201801178

2365-6549

Atsumi Sasayama, Keiko Akita, Hiroto Oya, Takashi Kikuchi, Yasuko In, Mihoyo Fujitake, Takeshi Yamada, Reiko Tanaka,

Insect Pest Control Strategies

Abstract Two novel chukrasone‐type limonoids, Guianofruits A and B ( 1 and 2 ) were isolated from the fruit oil of Carapa guianensis A UBLET (Meliaceae), a traditional medicine in Brazil and Latin American countries. Their structures were elucidated based on spectroscopic analyses using 1D and 2D NMR techniques, HRFABMS, and X‐ray crystallography. Compounds 1 and 2 were rare chukrasone‐type limonoids that had once been isolated from Chukrasia tabularis . Compounds 1 and 2 were evaluated for their effects on the production of NO in LPS‐activated mouse peritoneal macrophages. The results of the NO inhibitory assay suggested that compound 1 is valuable as a potential inhibitor of macrophage activation.