Portal de Periódicos da CAPES

Artigo Produção Nacional Revisado por pares

BIBTEX RIS

Atypical Squamous Cells: Cytopathological Findings and Correlation with HPV Genotype and Histopathology

2018; Karger Publishers; Volume: 62; Issue: 5-6 Linguagem: Inglês

10.1159/000489386

1938-2650

Geilson Gomes de Oliveira, Judite Maria da Silva Costa de Oliveira, Renata Mírian Nunes Eleutério, Rita de Cássia Carvalho Barbosa, Paulo Roberto Carvalho de Almeida, José Eleutério,

Molecular Biology Techniques and Applications

<b><i>Objective:</i></b> We aimed to assess potential associations between atypical squamous cell (ASC) subgroups: ASC-US (undetermined significance) and ASC-H (cannot exclude high-grade squamous intraepithelial lesion), regarding cytomorphological features, high-risk (HR) human papillomavirus (HPV) testing, and histological outcomes in a sample of Brazilian women. <b><i>Study Design:</i></b> Cross-sectional study which evaluated 1,346 liquid-based cytologies between January 2010 and July 2016 with ASC results. ASC-US and ASC-H were analyzed for frequency, diagnostic criteria, and cytological findings and compared with HR-HPV tests and histological outcomes. <b><i>Results:</i></b> Enlarged nucleus was the most frequent ASC-US criterion, but alternative criteria were present in 20% of the total cases. No ASC-US criteria were associated with histological outcomes or HR-HPV positivity. Parakeratosis, corneal pearl, giant cells, and binucleation were strongly associated with ASC-US while hyperkeratosis was associated with high-grade squamous intraepithelial lesions (HSIL) or a superior outcome. HR-HPV was positive in 64.39% of ASC-US and 65.38% of ASC-H. HSIL or superior outcomes also occurred in 13.33% of ASC-US and 64.71% of ASC-H cases. <b><i>Conclusion:</i></b> Alternative criteria for ASC-US were relatively frequent. Reactive cellular changes suggestive of atypias were more abundant in ASC-US. Although ASC-H is associated with worse histological outcomes, no differences in HPV positivity were found in comparison to ASC-US.