Produção Nacional
Revisado por pares
PP.20.22
2015; Lippincott Williams & Wilkins; Volume: 33; Issue: Supplement 1 Linguagem: Inglês
10.1097/01.hjh.0000468334.21911.2f
ISSN1473-5598
AutoresLuiz Aparecido Bortolotto, Marcio Gonçalves Souza, Valéria Costa Hong, D Giorgi, Heno Ferreira Lopes, Luciano F. Drager, Fernanda Marciano Consolim‐Colombo, Eduardo Moacyr Krieger,
ResumoObjective: Functional and structural properties of large arteries have been studied for the better understanding of vascular lesions linked to arterial hypertension, but patients with severe hypertension, more suitable for complications, has not been evaluated. The aim of our study was to evaluate modifications of large arteries obtained by noninvasive methods, its major determinants and the correlations with end-organ damage and the ambulatory arterial stiffness index (AASI) in patients with severe hypertension. Design and method: We evaluated 48 patients (age 53,6 ± 8 years; 75% white; 71% women), with stage 3 arterial hypertension, under the same antihypertensive treatment for one month. Carotid parameters (diameter, wall thickness, distension) were evaluated by radiofrequency ultrasound arterial stiffness by pulse wave velocity (PWV) measurements and AASI obtained by 24-hs ambulatory blood pressure monitoring. It was performed echocardiogram and biochemical profile. Results: We observed increased arterial stiffness by elevated PWV values (12.4 m/s) and AASI (0.4). It was observed a significant correlation between PWV and AASI(r = 0.10, p = 0.032). Carotid distension was lower in diabetic patients. We found that age was positively correlated with PWV (r = 0.53, p < 0.001), AASI (r = 0.35, p = 0.016) and carotid diameter (r = 0.40, p = 0.005). There was a negative correlation between blood glucose levels and carotid distension (r = -0.32, p = 0.026) and the carotid diameter was positively related to hemoglobin levels (r = 0.28, p = 0.049). We did not observe any significant correlation among laboratory variables and measures of IMT and PWV. The AASI was significantly related to blood glucose levels (r = 0.29, p = 0.045). Carotid distension was significantly lower in patients with diabetes (3.4% vs 7.3%, p = 0.03). The main independent determinant of PWV was age while glycemia was the main determinant of AASI. Conclusions: Patients with stage 3 hypertension had important modifications of functional properties of large arteries that are impaired by aging and association of diabetes.
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