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An intriguing relationship between the cyclic diguanylate signaling system and horizontal gene transfer

2018; Springer Nature; Volume: 12; Issue: 9 Linguagem: Inglês

10.1038/s41396-018-0183-0

1751-7370

Jonas Stenløkke Madsen, Ole Hylling, Samuel Jacquiod, S. Pécastaings, Lars Hestbjerg Hansen, Leise Riber, Gisle Vestergaard, Søren J. Sørensen,

Cancer Research and Treatments

The second messenger cyclic diguanylate (c-di-GMP) is ubiquitously used by bacteria to modulate and shift between different phenotypes including motility, biofilm formation and virulence. Here we show that c-di-GMP-associated genes are widespread on plasmids and that enzymes that synthesize or degrade c-di-GMP are preferentially encoded on transmissible plasmids. Additionally, expression of enzymes that synthesize c-di-GMP was found to increase both biofilm formation and, interestingly, conjugative plasmid transfer rates.