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Azithromycin for Early Pseudomonas Infection in Cystic Fibrosis. The OPTIMIZE Randomized Trial

2018; American Thoracic Society; Volume: 198; Issue: 9 Linguagem: Inglês

10.1164/rccm.201802-0215oc

1535-4970

Nicole Mayer-Hamblett, George Retsch‐Bogart, Margaret Kloster, Frank J. Accurso, Margaret Rosenfeld, Gary M. Albers, Philip Black, Perry Brown, AnneMarie Cairns, Stephanie D. Davis, Gavin R. Graff, Gwendolyn S. Kerby, David M. Orenstein, Rachael Buckingham, Bonnie W. Ramsey, George Retsch‐Bogart, Frank J. Accurso, Rachael Buckingham, Michelle S. Howenstine, Susan Jacob, Richard Kronmal, Robert Kuhn, Nicole Mayer-Hamblett, Karen McCoy, David P. Nichols, Bonnie W. Ramsey, Margaret Rosenfeld, Scott D. Sagel, Lisa Saiman, John Sheridan, Benjamin S. Wilfond, Edith T. Zemanick, Irene Bondick, Lauren Braam, Margaret Brassil, Rachael Buckingham, Missy Cianciola, Sonya L. Heltshe, Susan Jacob, Miya Johnson, Jean Kirihara, Margaret Kloster, Ada Kong, S. Ma, Sharon McNamara, Lindsey Mann, Kelly Moormann, Matthew Myers, Nicole Mayer-Hamblett, Bonnie W. Ramsey, George Retsch‐Bogart, Kathy Seidel, M. Skalland, Carmen A. Ufret-Vincenty, Jill M. VanDalfsen, Christopher H. Goss, David Horné, Erin K. Kross, Peter J. Leary, Kathleen J. Ramos, Patricia Roush, Jack C. Salerno, Gregory J. Omlor, D. Ouellette, Deanna Green, Kathy Hosler, Adrienne P. Savant, Zainub Ashrafi, Ariel Berlinski, Andrea Ross, Gregory S. Sawicki, Robert Fowler, Monica Ulles, Gary M. Albers, Freda Branch, Kevin Kirchner, Kerry DiBenardo, Gwendolyn S. Kerby, Meg Anthony, Thomas G. Keens, Alejandra Franquez, Carmen Reyes, Ibrahim Abdulhamid, Catherine Van Wagnen, David M. Orenstein, Elizabeth Hartigan, Carley Mihlo, Ronald B Williams, Margaret Lessard, Laura A. Sass, Erin McAndrews, Jennifer M. Parrott, Julie Noe, Patricia Hastings, Theresa Kump, John Clancy, Stacey Niehaus, Lisa Saiman, Juyan Zhou, Gary A. Mueller, Sandy Bartosik, Jason Fullmer, Colleen Millian, Arlene A. Stecenko, Joy Dangerfield, Gavin R. Graff, Diane Kitch, AnneMarie Cairns, Carrie Milliard, Robert Zanni, Bridget Marra, Karen McCoy, P. Guittar, Melinda Smith, David J. Schaeffer, E Deluca, John Welter, Meighan M. Gallagher, Armando Ramirez, Alexandra Cornell, Erika Simeon, Dion Roberts, Katherine Nelson, James F. Chmiel, Cindy Schaefer, Stephanie D. Davis, Lori Shively, James Wallace, Allisa Richter, Bonnie W. Ramsey, Sharon McNamara, Jessica E. Pittman, Tina Hicks, Perry Brown, Dixie Durham, Carlos Milla, Jacquelyn Zirbes, Christopher N. Fortner, Valoree Suttmore, Philip Black, Rose Thompson, Cori Daines, Mónica Varela, Timothy D. Starner, M. Teresi, Samya Z. Nasr, Dawn Kruse, Heather Thomas, Lisa Houdesheldt, George Retsch‐Bogart, Carol Barlow, Rose Cunnion, Saumini Srinivasan, Catherine Horobetz, Fadi Asfour, Jessica Francis, Michael J. Rock, Linda Makholm, Marie E. Egan, Catalina Guzman,

Pneumonia and Respiratory Infections

New isolation of Pseudomonas aeruginosa (Pa) is generally treated with inhaled antipseudomonal antibiotics such as tobramycin inhalation solution (TIS). A therapeutic approach that complements traditional antimicrobial therapy by reducing the risk of pulmonary exacerbation and inflammation may ultimately prolong the time to Pa recurrence.