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In-vivo imaging of tumor-infiltrating immune cells: implications for cancer immunotherapy

2018; Volume: 62; Issue: 1 Linguagem: Inglês

10.23736/s1824-4785.17.03052-7

1827-1936

Carolien Zeelen, Carmen Paus, Derk Draper, Sandra Heskamp, Alberto Signore, Filippo Galli, Cristoph M. Griessinger, Erik H.J.G. Aarntzen,

Immune Cell Function and Interaction

The QuarTerly Journal of nuclear Medicine and Molecular iMaging March 2018 for many cancer types, but consistently only a limited subset of patients.especially in cancer types with high mutation rates, e.g.melanoma, non-small cell lung cancer and renal cancer, showed effective responses to immunotherapeutic approaches. in addition to high costs and serious toxicity profiles, the lack of tools to measure the behavior of immune cell populations hampers efficient application of immune therapy.With respect to immunotherapy, immune cell populations such as cytotoxic cd8 + T-cells, cd56 + nK cells and myeloid phagocytic cells play decisive roles, exemplified in immune checkpoint inhibitor therapy.Target-d ynamic and reciprocal interactions between tumor cells and immune cells promote the initiation, progression, metastasis and therapy-resistance of cancer.2][3] in the past years, several immunotherapies have successfully been introduced in the clinic aiming to increase the number and activity of tumor-infiltrating immune cells, e.g.immune checkpoint inhibitors, adoptive T-cell transfer, chimeric antigen receptor (car) T-cells and dendritic cell-based (dc) vaccines.