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Zinc supplementation reduces inflammation in ulcerative colitis patients by downregulating gene expression of Zn metalloproteins

2018; Elsevier BV; Volume: 6; Issue: 3 Linguagem: Inglês

10.1016/j.phanu.2018.06.004

2542-520X

Nina Rosa Mello Soares, Mayara Storel Beserra de Moura, Flaviane Alves de Pinho, Tomas Magno Costa Silva, Susy Érika de Lima Barros, Amanda de Castro Amorim, Edivan Carvalho Vieira, José Machado Moita Neto, José Miguel Luz Parente, Maria do Socorro Pires e Cruz, Dilina do Nascimento Marreiro, Nadir do Nascimento Nogueira,

Tuberculosis Research and Epidemiology

Ulcerative colitis is a disease mainly characterized by chronic inflammation and an increased production of pro inflammatory cytokines and reactive oxygen species, which are frequently associated with zinc (Zn) deficiency. Zn supplementation can be beneficial to the treatment of ulcerative colitis, because of the anti-inflammatory and antioxidant properties of Zn. A blind intervention study involving 41 patients diagnosed with ulcerative colitis, aimed at evaluating the effect of Zn supplementation (35 mg Zn gluconate/day for 30 days) on the plasma and erythrocyte concentrations of Zn, the gene expression of metallothionein 1 G (MT1G) and ZIP-14, and the serum levels of TNF-α, IL-6, IL-10 was performed. Significant increases in the plasma and erythrocyte concentrations of Zn were observed after Zn supplementation (p < 0.01 and p = 0.04 respectively). At the end of the experiment, it was found that the concentrations of TNF-α, IL-6, and IL-10in serum did not vary significantly from those at baseline. MT1G and ZIP-14 gene expression reduced significantly after supplementation (p = 0.04 for both genes). In conclusion, Zn supplementation downregulates the expression of metalloproteins that transport Zn, causing a higher accumulation of Zn, and supporting a correlation between Zn homeostasis and immune response in ulcerative colitis.