CRAN-32. CASE BASED LEARNING: THREE CENTURIES OF LESSONS FROM TWO CRANIOPHARYNGEOMA PATIENTS
2018; Oxford University Press; Volume: 20; Issue: suppl_2 Linguagem: Inglês
10.1093/neuonc/noy059.068
ISSN1523-5866
AutoresJohn Apps, J. Ciaran Hutchinson, Susan C. Shelmerdine, Alex Virasami, Eduard Winter, Thomas S. Jacques, Juan-Pedro Martinez-Barbera, Owen J. Arthurs, Thomas Czech,
Tópico(s)Multiple Myeloma Research and Treatments
ResumoCase-based learning is a core component of medical undergraduate curricula across the world; it has been used to impart knowledge of human physiology, symptomatology, pathology, and clinical therapy for millenia. We present two cases of craniopharyngeoma (CP) where separate studies at different time points between 1839 and 2017 have impacted on our understanding of the normal function of the pituitary and the hypothalamus as well as the classification of its pathology. Based on 2 specimens of CP stored in the Pathological-Anatomical Museum in Vienna, Austria, we retraced the clinical-pathological analyses of these cases starting in 1839 by Josef Engel under the auspices of Karl von Rokitansky, one of the fathers of modern pathology, reanalysed in detail by Jakob Erdheim in his 1904 paper recognizing these „hypophyseal duct tumors“ as a pathologic entity of its own. Ever since H.Cushing (improperly) renamed them craniopharyngeomas they remain one of the „most formidable intracranial tumors“ despite recent advances in understanding their molecular biology. Lastly in 2017 the two samples were reanalysed in London (UK) by advanced imaging (3T MR and high-resolution micro-CT) supplementing histological studies. The conclusions of the separate studies highlight how the interpretation of data is shaped by the technologies/methodologies and prevailing theories of the time.
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