Portal de Periódicos da CAPES

Revisão Acesso aberto Produção Nacional Revisado por pares

BIBTEX RIS

Anti-Inflammatory Effects of Resveratrol: Mechanistic Insights

2018; Multidisciplinary Digital Publishing Institute; Volume: 19; Issue: 6 Linguagem: Inglês

10.3390/ijms19061812

1661-6596

Diego de Sá Coutinho, Marcos Tadeu Tavares Pacheco, Rudimar Luiz Frozza, Andressa Bernardi,

Calcium signaling and nucleotide metabolism

Inflammation is the principal response invoked by the body to address injuries. Despite inflammation constituting a crucial component of tissue repair, it is well known that unchecked or chronic inflammation becomes deleterious, leading to progressive tissue damage. Studies over the past years focused on foods rich in polyphenols with anti-inflammatory and immunomodulatory properties, since inflammation was recognized to play a central role in several diseases. In this review, we discuss the beneficial effects of resveratrol, the most widely investigated polyphenol, on cancer and neurodegenerative, respiratory, metabolic, and cardiovascular diseases. We highlight how resveratrol, despite its unfavorable pharmacokinetics, can modulate the inflammatory pathways underlying those diseases, and we identify future opportunities for the evaluation of its clinical feasibility.