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Synthesis, spectroscopy, electrochemistry and DNA interactive studies of meso-tetra(1-naphthyl)porphyrin and its metal complexes

2018; Elsevier BV; Volume: 482; Linguagem: Inglês

10.1016/j.ica.2018.06.052

1873-3255

Carolina Hahn da Silveira, Emanuelly N. Garoforo, Otávio Augusto Chaves, Paulo Fernando Bruno Gonçalves, Lívia Streit, Bernardo A. Iglesias,

DNA and Nucleic Acid Chemistry

A simple methodology to design metal-free porphyrin (meso-tetra-(1-naphthyl)porphyrin) and their corresponding transition metal complexes (Zn(II), Cu(II), Ni(II), Co(III) and Mn(III)) is described. These porphyrins were fully characterized by elemental analysis, HRMS-ESI, UV–vis absorption, steady state fluorescence emission, theoretical calculations and electrochemical analysis. Photo-stability and singlet oxygen generation species were also evaluated. Spectroscopic studies and molecular docking calculations evinced the ability of each porphyrin derivatives to establish interactions with calf-thymus DNA (ct-DNA).