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Immunoexpression of SOX ‐2 in oral leukoplakia

2018; Wiley; Volume: 24; Issue: 8 Linguagem: Inglês

10.1111/odi.12922

1601-0825

Suelen Teixeira Luiz, Filipe Modolo, Izabela Mozzer, Emanuela Carla dos Santos, Seigo Nagashima, Ana Paula Camargo Martins, Marina Luise Viola de Azevedo, Luciana Reis Azevedo‐Alanis, Ana Maria Trindade Grégio, Rafaela Scariot de Moraes, Maria Cássia Ferreira de Aguiar, Sérgio Aparecido Ignácio, Bruno Correia Jham, Lúcia de Noronha, Aline Cristina Batista Rodrigues Johann,

Salivary Gland Tumors Diagnosis and Treatment

Abstract Objective This study was conducted to correlate and compare the immunoexpression of sex‐determining region Y‐box 2 ( SOX ‐2) in oral leukoplakia ( OL ) lesions with that in normal buccal mucosa (control). Materials and Methods In this observational study, OL with low‐risk ( n = 34) and high‐risk ( n = 33) dysplasia and control samples ( n = 25) were subjected to immunohistochemical analysis for SOX ‐2. In the epithelium, SOX ‐2 positive and negative cells, as well as semiautomatic segmentation of the immunopositive nuclear area were counted. Statistical tests included chi‐square, one‐way analysis of variance, Tukey, and Games‐Howell. The level of significance was 5%. Results Groups with OL lesions (low and high‐risk) showed higher mean numbers of SOX ‐2 positive cells (63.47 ± 25.70 and 68.18 ± 21.17) compared to the control group (45.85 ± 27.38) ( p = 0.00). Groups with OL lesions (low and high‐risk) exhibited higher mean positive nuclear area (0.24 ± 0.47 and 1.09 ± 2.06) compared to the control group (0.00 ± 0.01) ( p = 0.01). Conclusion Oral leukoplakia lesions showed a higher expression of SOX ‐2, suggesting its contribution to the pathogenesis of OL .