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GC-MS BASED CHEMICAL PROFILING AND EVALUATION OF ANTIOXIDANT POTENTIAL OF LEAVES AND STEMS OF ALTERNANTHERA SESSILIS RED FROM SABAH, MALAYSIA

2018; Innovare Academic Sciences; Volume: 10; Issue: 7 Linguagem: Inglês

10.22159/ijpps.2018v10i7.25204

2656-0097

Mohammad Shaheen Khan, Samina Khan Yusufzai, Lim Yi Ying, Wan Zulnashriq,

Medicinal Plant Research

Objectives: The aim of the current study was to perform phytochemical screening and determination of total phenolics, total flavonoids and antioxidant activity of various crude extracts of Alternanthera sessilis red leaves.Methods: Determination of antioxidant nature of Alternanthera sessilis red was carried out by DPPH radical scavenging method. GC-MS analysis of various crude extracts resulted in the presence of different types of low and high molecular weight compounds consisting of carbohydrates, fatty acid and vitamins.Results: Among all the extracts, methanol extracts exhibited higher DPPH radical scavenging activity with IC50 value of 0.183 mg/ml. BHT used as the positive control showed IC50 value of 0.089 mg/mL. The results suggested that the crudes extracts of Alternanthera sessilis red exhibit moderate antioxidant activity. The total phenolic content (279.8 ± 0.02 mg GAE/g) and total flavonoid content (250.7 ± 0.03 mg QE/g) in methanol was estimated higher as compared to other solvents.Conclusion: The total flavonoid content and total phenolic content were found to be higher in methanolic extract followed by ethyl acetate and hexane extracts.