Portal de Periódicos da CAPES

Identification of a new subset of lymph node stromal cells involved in regulating plasma cell homeostasis

2018; National Academy of Sciences; Volume: 115; Issue: 29 Linguagem: Inglês

10.1073/pnas.1712628115

1091-6490

Hsin-Ying Huang, Ana Rivas-Caicedo, François Renevey, Hélène Cannelle, Elisa Peranzoni, Léonardo Scarpellino, Debbie L. Hardie, Arnaud Pommier, Karin Schaeuble, Stéphanie Favre, Tobias K. Vogt, Fernando Arenzana‐Seisdedos, Pascal Schneider, Christopher D. Buckley, Emmanuel Donnadieu, Sanjiv A. Luther,

Immune Cell Function and Interaction

Significance Lymph nodes (LNs) are sites where adaptive immunity is initiated, leading to the generation of plasma cells (PCs) secreting large amounts of antibodies that typically interfere with pathogen spread. PCs are known to depend on extrinsic factors provided by niche cells to stay alive; however, the critical niche cells are still poorly understood. Here we present evidence for a fibroblast subset within murine and human LNs that is unique to the medulla where PCs reside. These fibroblasts produce factors that positively regulate PC homeostasis, similar to macrophages. Knowing the critical niche cells may help to design intervention strategies to target this niche in the setting of autoimmune disease caused by PCs secreting autoreactive antibodies.